Interferon Beta (IFN B or IFN β) is a human cytokine encoded by the IFNB1 gene. IFN B belongs to the Interferon type I family that regulates the immune system in humans. They are present in all mammals. Interferon Beta or IFN B or IFN β gene is a human cytokine encoded by the IFNB1 gene. It belongs to the Interferon type I family that regulates the immune system in humans. Thus, it has properties like anticancer, antibacterial and antiviral properties. It is responsible for immune responses to viral antigens. IFNB1 and IFNB3 are two subtypes of this protein. Interferon Beta is a cell surface receptor complex consisting of two chains, IFNAR1 and IFNAR2. When it binds to the IFNB proteins, released by fibroblasts, in response to an evasive pathogen, it initiates the first line of defence against invasion like bacterial, viral and cancer cells. This system works in conjunction with the CD74 receptors on other cells like the WBC’s that release MIF proteins into circulation for a long term defence strategy. MIF binds to the CD74 receptors on cells. These cells then orchestrate an acute immune response to bacterial infections and disrupt autoreactive immune processes. Alterations in MIF levels has been linked to neurodegenerative diseases, malignancies, and human immunodeficiency virus (HIV)-related neurocognitive disorders.
Brain natriuretic peptide (BNP), is a hormone secreted by the heart. It facilitates fluid retention, causes the heart to stretch and pump more blood. BNP is produced by the heart continuously as pro-BNP. An enzyme Corin splits pro-BNP and releases two moieties, a 32-amino acid polypeptide active hormone BNP and a non-active 76-amino acid N-terminal prohormone NT-proBNP that also abbreviated as BNPT. Brain natriuretic peptide (BNP, also referred to as ventricular natriuretic peptide or B-type natriuretic peptide) is a hormone secreted by the human heart. Cardiomyocytes or cardiac muscles in the left ventricle secrete BNP. The left ventricle pumps oxygenated blood to different parts of the body and therefore controls blood pressure and volume. Brain natriuretic peptide (BNP), also referred to as ventricular natriuretic peptide or B-type natriuretic peptide, is a hormone secreted by the human heart. The heart continually produces and releases BNP into the bloodstream in response to high blood pressure and overstretching of the chambers of the heart caused by conditions like hypertension and heart failure. BNP facilitates fluid retention and volume expansion in the veins and arteries and causes the heart to stretch and pump more blood.
B type natriuretic peptide function is a hormone secreted by the heart. It functions in cases of left ventricle dysfunction and congestive heart failure, helping to drive the volume of blood back into the veins and arteries. BNP is secreted by the heart. It helps the body maintain low blood pressure and volume. Increased levels of BNP are associated with various illnesses including heart valve disease, kidney disease, heart failure, asthma, and liver cirrhosis. Measurement of NT-proBNP can be used in screening patients for conditions that can cause heart ailments.
BNP is a hormone secreted by the heart. It causes blood vessels to relax and dilate, making it easier for your heart to pump and lowering your blood pressure. In the urine, BNP activates a receptor protein called natriuretic receptor-A (NPR-A). Other functions of BNP and NT-proBNP include muscle contraction in the kidneys, maintaining balance of electrolytes and water inside and outside cells.
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